Messenger RNA Structure: Compatibility of Hairpin Loops with Protein Sequence

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Science  17 Mar 1972:
Vol. 175, Issue 4027, pp. 1264-1266
DOI: 10.1126/science.175.4027.1264


Examination of the amino acid sequences of human cytochrome c and the α-chain variant of human hemoglobin Constant Spring has revealed the possiblity for base-paired hairpin loops in the messenger RNA's for these proteins. A similar analysis of the bacteriophage R17 coat protein suggests an additional unobserved loop in the R17 RNA. If such loops are present in messenger RNA's generally, it would suggest that DNA has more than one stable base-paired conformation.