Iodine Metabolism: Preferential Renal Excretion of Iodide Derived from Triiodothyronine Deiodination

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Science  17 Mar 1972:
Vol. 175, Issue 4027, pp. 1266-1267
DOI: 10.1126/science.175.4027.1266


Measurements were made in rats of the relative rates of accumulation in urine or in the thyroid of radioactive iodide derived from simultaneous injections of 131I-labeled triiodothyronine and 125I-labeled iodide. The data indicate that deiodination of triiodothyronine by the kidney results in a loss into the urine of iodine which does not enter the general body iodide pool. This renal "iodide leak" should be considered in kinetic models of iodine metabolism.