Reports

Galactose Utilization in Galactosemia

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Science  24 Mar 1972:
Vol. 175, Issue 4028, pp. 1368-1370
DOI: 10.1126/science.175.4028.1368

Abstract

Cultures of human galactosemic fibroblasts without detectable transferase activity were able to convert [1-14C]galactose to 14CO2 to the same extent as normal cells, but did so at a significantly slower rate. The utilization of galactose in both normal and galactosemic cells was strongly inhibited by glucose at physiologic concentrations.

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