Oxygen Affinity in Red Cells: Changes Induced in vivo by Propranolol

Science  24 Mar 1972:
Vol. 175, Issue 4028, pp. 1372-1373
DOI: 10.1126/science.175.4028.1372


Propranolol, a blocking agent for the beta adrenergic receptor, produces a redistribution of 2,3-diphosphoglycerate in the red cell. At concentrations of 3.3 x10-5M, 2,3-diphosphoglycerate in the red cell membrane becomes unbound in vitro. The administration of propranolol to hunmns produces similar changes and results in a decrease in the affinity of hemoglobin for oxygen.