Acetylcholine:Possible Neuromuscular Transmitter in Crustacea

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Science  24 Mar 1972:
Vol. 175, Issue 4028, pp. 1373-1375
DOI: 10.1126/science.175.4028.1373


The tonic flexor muscles of the crayfish abdomen respond with a large depolarizing potential to acetylcholine iontophoresed onto a neuromuscular Junction, but not to glutamate. Excitatory junctional potentials are abolished by d-tubocurarine and enhanced by a cholinesterase inhibitor. The membrane is depolarized and the junctional potentials are desensitized by excess acetylcholine. Thus acetylcholine is thought to be the neuromuscular transmitter.