Biogenic Amine Metabolites in Cerebrospinal Fluid of Depressed and Manic Patients

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Science  24 Mar 1972:
Vol. 175, Issue 4028, pp. 1380-1382
DOI: 10.1126/science.175.4028.1380


A reduction in 5-hydroxyindoleacetic acid in cerebrospinal fluid was found in depressed and manic patients both while they were symptomatic and also after treatment. The concentration of homovanillic acid was initially reduced and then tended to increase after treatment.