Genetic Variation in Human Erythrocyte Acetylcholinesterase

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Science  31 Mar 1972:
Vol. 175, Issue 4029, pp. 1466-1467
DOI: 10.1126/science.175.4029.1466


A method for solubilization of human erythrocyte membranes was developed and used to survey 70 unselected human blood samples for isozymic variation of stromal acetylcholinesterase. Three variants were observed. Pedigrees of families studied by this method indicated that this variation represented the phenotypic expression of two codominant alleles at a single locus.