Transfer Factor from Guinea Pigs Sensitive to Dinitrochlorobenzene: Absence of Superantigen Properties

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Science  31 Mar 1972:
Vol. 175, Issue 4029, pp. 1473-1475
DOI: 10.1126/science.175.4029.1473


Transfer factor from guinea pigs sensitive to dinitrochlorobenzene was not bound to an immunoadsorbent column that is specific for the dinitrophenyl determinant. The absence of the dinitrophenyl determinant on transfer factor suggested that the factor does not function as superantigen. The duration of the adoptive sensitivity, the small molecular weight, and the polypeptide or polynucleotide (or a combination) composition of the transfer factor are consistent with a derepressor function of the molecule.