Genetic Control of Lactate Dehydrogenase Expression in Mammalian Tissues

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Science  14 Apr 1972:
Vol. 176, Issue 4031, pp. 180-181
DOI: 10.1126/science.176.4031.180


The amount of lactate dehydrogenase isozyme 4 in erythrocytes of mice is controlled by alleles at the Ldr-1 locus. The A subunits of lactate dehydrogenase from erythrocytes deficient in isozyme 4 cannot assemble in vitro with B subunits to form active isozyme. The inability to form hybrid enzyme is not due to a mutation in the structural gene for the A polypeptide. Rather, a factor that is bound to the A subunits of erythrocytes restricts free exchange with B subunits.