Acetylcholine Receptors: Number and Distribution at Neuromuscular Junctions in Rat Diaphragm

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Science  14 Apr 1972:
Vol. 176, Issue 4031, pp. 189-191
DOI: 10.1126/science.176.4031.189


The number of acetylcholine receptors per motor end plate in the rat diaphragm, measured by the binding of [1251]α-bungarotoxin, varies directly with rat size and is (4.0 ± 0.2) x 107 for full-grown male rats. Autoradiographic analysis of single fibers labeled with this substance reveals that virtually all of these receptors are localized in the end plate.