Synergy of Ethanol and Putative Neurotransmitters: Glycine and Serine

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Science  21 Apr 1972:
Vol. 176, Issue 4032, pp. 292-294
DOI: 10.1126/science.176.4032.292


The putative neurotransmitters, glycine and serine, significantly enhanced the sleeping time (loss of the righting reflex) that was induced by ethanol in mice. The observed synergistic effect between ethanol and the amino acids is probably not related to an alteration of ethanol metabolism, but rather to an interaction of these compounds in the central nervous system.