Carboxyhemoglobin Elevation after Exposure to Dichloromethane

Science  21 Apr 1972:
Vol. 176, Issue 4032, pp. 295-296
DOI: 10.1126/science.176.4032.295


Inhalation of dichloromethane vapor in concentrations of 500 to 1000 parts per million for 1 to 2 hours promptly initiated the formation of significant quantities of carbon monoxide in human subjects. The evidence suggests that carbon monoxide may be a metabolite of dichloromethane and, that exposure to concentrations of dichloromethane below the industrial threshold limit values may result in the formation of carbon monoxide in amounts that exceed the allowable limits.