Neuromuscular Transmission: Inhibition by Manganese Ions

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Science  21 Apr 1972:
Vol. 176, Issue 4032, pp. 308-309
DOI: 10.1126/science.176.4032.308


Manzganiese ions. are potent blocking argenits of synaptic transmission at the neuromuscular junction in the frog. The main site of action is the presynaptic nerve terminal, where the ions decr-ease the amount of transmitter liberated by a never impulse. The inihibition produced by manganese is reversible.