Ergot-Induced Inhibition of Pituitary Tumor Growth in Rats

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Science  28 Apr 1972:
Vol. 176, Issue 4033, pp. 417-418
DOI: 10.1126/science.176.4033.417


Daily injections of ergocornine or ergonovine, for 3 weeks, into rats carrying a prolactin- and growth hormone—secreting pituitary tumor (MtW15) induced significant regression or inhibition of tumor growth, whereas ergocryptine had no significant effect. Ergocornine caused a decrease in cells and a disappearance or pycnosis of nuclei in the tumor tissue, and a reduced concentration of prolactin in blood.