Isolation and Characterization of Two Major Urinary Metabolites of Δ1-Tetrahydrocannabinol

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Science  28 Apr 1972:
Vol. 176, Issue 4033, pp. 422-423
DOI: 10.1126/science.176.4033.422


Two of the major metabolites which appear in rabbit urine after the administration of Δ1-tetrahydrocannabinol have been isolated and their structures have been tentatively established. The available evidence indicates that they are 7-carboxy-Δ1-tetrahydrocannabinols with an additional hydroxyl group on the side chain. The substances occur both free and as conjugates.