Trophic Regulation of Acetylcholine Sensitivity of Muscle: Effect of Electrical Stimulation

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Science  05 May 1972:
Vol. 176, Issue 4034, pp. 514-516
DOI: 10.1126/science.176.4034.514


Denervation of skeletal muscle results in a spread of acetylcholine sensitivity over the entire surface membrane. Electrical stimulation, programmed to mimic the normal activity pattern, was applied continuously to the denervated rat diaphragm in vivo. After 4 days, the acetylcholine sensitivity was far less in the stimulated diaphragms than in denervated controls. Muscle activity may account for "neurotrophic" regulation of the acetylcholine sensitivity.