Salicylate: Action on Normal Body Temperature in Rats

See allHide authors and affiliations

Science  05 May 1972:
Vol. 176, Issue 4034, pp. 532-533
DOI: 10.1126/science.176.4034.532


Rats receiving intraperitoneal injections of sodium salicylate (30 to 300 milligrams per kilogram of body weight) showed a decline in rectal temperature of up to 5.5°C when placed in a 5°C environment. High dosages of salicylate lowered the rectal temperatures of rats kept in a 23°C environment. The finding that salicylate can lower nonfebrile body temperature suggests that this class of antipyretic agents does affect normal temperature regulation.