Cribriform Degeneration (cri): A New Recessive Neurological Mutation in the Mouse

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Science  19 May 1972:
Vol. 176, Issue 4036, pp. 800-803
DOI: 10.1126/science.176.4036.800


The mutation cribriform degeneration (cri) occurred in the DBA/2J strain; it is in linkage group VIII, 31 recombination units from b. Homozygotes show severe vacuolar degeneration in white and gray matter of the spinal cord and brainstem, normocytic anemia at birth which decreases in severity with age, and abnormalities of electrolyte distribution.