Hyperprolinemia and Prolinuria in a New Inbred Strain of Mice, PRO/Re

Science  19 May 1972:
Vol. 176, Issue 4036, pp. 809-811
DOI: 10.1126/science.176.4036.809


A hyperprolinemia was discovered, in a new inbred strain of mice, which was equivalent to about a sevenfold elevation above the concentration of proline in the blood of either of the original parental lines, or of 12 other inbred strains with diverse genetic constitution. In addition, mice of this PRO/Re strain exhibited a marked prolinuria, whereas the other 14 inbred strains had no proline detectable in their urine.