Effects on Humans of ▵9-Tetrahydrocannabinol Administered by Smoking

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Science  26 May 1972:
Vol. 176, Issue 4037, pp. 934-936
DOI: 10.1126/science.176.4037.934


Twelve chronic marijuana users received ▵9-tetrahydrocannabinol by smoking. The magnitude of their pulse increment was highly correlated with their subjective experiences. Three of the 12 subjects subsequently received ▵9-tetrahydrocannabinol labeled with carbon-14; the time course of its concentration in plasma was highly correlated with the pulse increment. Subjective symptoms, however, appeared later and dissipated more slowly.