Genetic and Immunological Complexity of Major Histocompatibility Regions

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Science  02 Jun 1972:
Vol. 176, Issue 4038, pp. 1024-1027
DOI: 10.1126/science.176.4038.1024


There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.