Immunological Studies on Urinary Bladder Tumors of Rats and Mice

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Science  23 Jun 1972:
Vol. 176, Issue 4041, pp. 1337-1340
DOI: 10.1126/science.176.4041.1337


Human neoplasms derived from the same tissue have been previously shown to have tumor associated antigens characterizing that tissue type. Evidence is now presented for the existence of analogous antigens common to both rat bladder papillomas and carcinomas, and for antigens common to mouse bladder carcinomas. Rats immunized with syngeneic urinary bladder papillomas, then challenged with a methylcholanthrene pellet inserted into the bladder, develop (4 to 6 months later) fewer primary bladder tumors than rats immunized with normal bladder tissue.