Biosynthesis of Hemoglobin Ann Arbor: Evidence for Catabolic and Feedback Regulation

Science  30 Jun 1972:
Vol. 176, Issue 4042, pp. 1427-1429
DOI: 10.1126/science.176.4042.1427


Hemoglobin Ann Arbor, in which arginine replaces leucine in position 80 of the a chain, occurs in aflected individuals in low proportion to hemoglobin A. Biosynthetic studies were perforined on reticulocytes of a patient heterozygous for this hemoglobin. These studies suggested that the low percentage of hemoglobin Ann Arbor is prinlarily due to preferential destruction of the abnormal component. The reduced concentration of α Ann Arbor chains was also reflected in a decreased synthesis of normal β chains.