Indole-3-Acetic Acid in-Human Cerebrospinal Fluid: Identification and Quantification by Mass Fragmentography

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Science  07 Jul 1972:
Vol. 177, Issue 4043, pp. 74-76
DOI: 10.1126/science.177.4043.74


Indole-3-acetic acid has been identified in human cerebrospinal fluid by the gas chromatographic-mass spectrometric technique called mass fragmentography. A specific and sensitive method for quantitative determination of indole-3-acetic acid down to 2 nanograms per milliliter of cerebrospinal fluid has been developed. Samples of cerebrospinal fluid from 24 patients with depression contained 6.1 ± 3.1 (range 2.6 to 15.8) nanograms of indole-3-acetic acid per milliliter.