Genetics of the Antibody Response to Dextran in Mice

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Science  14 Jul 1972:
Vol. 177, Issue 4044, pp. 178-180
DOI: 10.1126/science.177.4044.178


The immune response to dextran having the α-1,3 linkage may be under the control of antibody structural genes. Mice that respond well to this antigen produce antibody restricted with respect to light chain class (λ) and to an antigenic determinant resulting from a particular heavy and light chain interaction. The response to dextran is controlled by a locus linked to the-heavy chain locus.