Oligothymidylates: Formation by Thermal Condensation of O2,5'-Cyclothymidine 3'-Phosphate

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Science  21 Jul 1972:
Vol. 177, Issue 4045, pp. 272-274
DOI: 10.1126/science.177.4045.272


Thermal activation of O2,5'-cyclothymidine 3'-phosphate in solution and in the solid state led to the formation of thymidine oligonucleotides containing up to approximately 12 nucleotide units. Only the 3',5' internucleotide diester bonds were formed. This polymerization occurs without the addition of any activating agent or catalyst.