Anemic Stess as a Trigger of Myelogenous Leukemia in the Unirradiated RF Mouse

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Science  21 Jul 1972:
Vol. 177, Issue 4045, pp. 274-276
DOI: 10.1126/science.177.4045.274


Ninety-six percent of mice that were bled of 50 percent of their blood volume when they were 9 weeks old succumbed to myelogenous leukemia by 15 months after phlebotomy, the majority of them dying between 7 and 10 months after this treatment. These results suggest that (i) anemia is an effective stress for triggering myelogenous leukemia in animals that are predisposed to the disease, (ii) the RF mouse is "naturally" prone to the development of myelogenous leukemia, and (iii) the concept of two-step de novo induction of myelogenous leukemia appears to be applicable in this animal.