Cytochalasin B Prevents Specific Sorting of Reaggregating Embryonic Cells

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Science  21 Jul 1972:
Vol. 177, Issue 4045, pp. 281-282
DOI: 10.1126/science.177.4045.281


The effect of cytochalasin B on specific sorting during reaggregation of embryonic chick heart and neural retina cells was studied. At a dose that did not measurably affect uptake of precursors of protein and RNA synthesis, ratios of potassium to sodium ions, and nonspecific aggregation, cytochalasin B disrupted the formation of the characteristic pattern of islands of heart cells within a retinal continuum.