Tumor Imunity in vitro: Destruction of a Mouse Ascites Tumor through a Cycling Pathway

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Science  04 Aug 1972:
Vol. 177, Issue 4047, pp. 433-434
DOI: 10.1126/science.177.4047.433


Lymphocytes in peritoneal exudate from BALB/c mice immunized against ascites leukemia EL4 are uniquely efficient at destroying 51chromiumlabeled EL4 cells in vitro. The lytic process depends upon the number of lymphocyte-tumor cell interactions. Efector lymphocytes are not inactivated as a result of lethal contact but can interact repeatedly with tumor cells.