Rapid Immunological Induction of Murine Lymphomas: Evidence for a Viral Etiology

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Science  11 Aug 1972:
Vol. 177, Issue 4048, pp. 524-525
DOI: 10.1126/science.177.4048.524


A graft-versus-host reaction induced in (SJL/J x C57BL/1)F1 hybrid mice by injection of SJL/J spleen cells resulted in 100 percent incidence of tumors at 40 days. Transplantation studies revealed that the tumors were antigenically C57BL/1. Since both SJL/J and C57BL/1 mice carry tumorigenic virus, the evidence suggests a viral etiology.