Facilitation of Recovery by α-Methyl-p-Tyrosine after Lateral Hypothalamic Damage

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Science  11 Aug 1972:
Vol. 177, Issue 4048, pp. 534-535
DOI: 10.1126/science.177.4048.534


Rats with bilateral lateral hypothalamic lesions die of starvation in approximately 7 days after surgery. Rats that were treated with α-methyl-p-tyrosine for 3 days prior to lateral hypothalamic surgery spontaneously eat, drink, and gain weight after surgery. These data suggest that recovery of function after lateral hypothalamic damage involves denervation supersensitivity.