Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]anthracene

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Science  18 Aug 1972:
Vol. 177, Issue 4049, pp. 618-619
DOI: 10.1126/science.177.4049.618


A mixed-function oxidase that requires reduced nicotinamide adenine dinucleotide phosphate, is carbon monoxide sensitive, and is drug-metabolizing is present in human lymphocytes and is increased to different levels by treatment with phytohemagglutinin, pokeweed mitogen, and a polycyclic hydrocarbon.