Insulin Insensitivity of Large Fat Cells

Science  18 Aug 1972:
Vol. 177, Issue 4049, pp. 626-628
DOI: 10.1126/science.177.4049.626


Large insulin-insensitive adipocytes from adult rats have normal binding capacities and affinities for insulin. Diminished insulin-like responses to spermine and reduced rates of glucose oxidation are also evident in these cells. The results indicate that the defect responsible for this insulin-resistant state exists in a step subsequent to insulin binding, possibly in transmission of the insulin-receptor "signal" since insensitivity occurs under conditions where glucose transport and oxidative processes are not apparently impaired.