Axonal Transport of Gangliosides in the Goldfish Optic Nerve

Science  18 Aug 1972:
Vol. 177, Issue 4049, pp. 630-633
DOI: 10.1126/science.177.4049.630


Radioactive glucosamine and N-acetylmannosamine injected into the goldfish eye are incorporated into gangliosides that undergo rapid axonal transport to the optic nerve terminals. All ganglioside fractions are labeled. These data provide the first evidence that axonal transport has a role in neuronal ganglioside function and metabolism.