Synthetic Scotophobin in Goldfish: Specificity and Effect on Learning

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Science  18 Aug 1972:
Vol. 177, Issue 4049, pp. 635-636
DOI: 10.1126/science.177.4049.635


Synthetic rat scotophobin was injected intracranially into common goldfish (Carassius auratus) which were then trained to avoid light or dark. The substance interacts with the learning process in goldfish in an apparently specific way, facilitating the acquisition of dark avoidance, a task homologous with that acquired by rats from which the natural peptide was isolated, while inhibiting acquisition of light avoidance.