Genetic Determination of Phenotypic Variation in Sickle Cell Trait

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Science  25 Aug 1972:
Vol. 177, Issue 4050, pp. 716-718
DOI: 10.1126/science.177.4050.716


Two genetic sources of variation influence the percentage of sickle cell hemoglobin found in heterozygotes. One factor is strongly related to the percentage of hemoglobin S in the carrier parent and appears to be determined by sickle hemoglobin isoalleles, whereas the other is related to racial background and may well be polygenic.