Mouse Leukemia: Depression of Serum Interferon Production

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Science  01 Sep 1972:
Vol. 177, Issue 4051, pp. 797-799
DOI: 10.1126/science.177.4051.797


Production of circulating interferon is significantly impaired in AKR/J mice after development of lymphoblastic leukemia and in Balb/c mice with clinical signs of Friend erythroblastic leukemia. This alteration has been observed with three interferon inducers, each one known to elicit an interferon response in different cells.