Curative Potencies against α-Amanitin Poisoning by Cytochrome c

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Science  01 Sep 1972:
Vol. 177, Issue 4051, pp. 808-809
DOI: 10.1126/science.177.4051.808


The fatalities occurring after ingestion of the poisonous mushroom Amanita phalloides are thought to be due to α-amanitin. Cytochrome c provided antidotal effects against a lethal dose of this toxin in mice. Significant survival was obtained even when the treatment was withheld for 8 hours. The enzyme was superior to a previously explored therapeutic regimen consisting of penicillin and its combination with chloramphenicol and sulfamethoxazole.