Behavioral Maintenance of High Concentrations of Blood Ethanol and Physical Dependence in the Rat

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Science  01 Sep 1972:
Vol. 177, Issue 4051, pp. 811-813
DOI: 10.1126/science.177.4051.811


Rats maintained on an intermittent food schedule with an available ethanol solution drink to excess (13.1 grams of ethanol per kilogram of body weight, daily). Removal of ethanol produces symptoms of physical dependence including death from tonic-clonic seizures. Overindulgence in oral self-administration of an aqueous ethanol solution, resulting in unequivocal physical dependence, approximates a model of human alcoholism.