Adenosine 3',5'-Monophosphate and N6-2'-O-Dibutyryl-Adenosine 3',5'-Monophosphate Transport in Cells

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Science  15 Sep 1972:
Vol. 177, Issue 4053, pp. 1002-1003
DOI: 10.1126/science.177.4053.1002


Incubation of Strain L cells in 0.15 millimolar adenosine 3',5'-monophosphate (cyclic AMP) increase the intracellular level of cyclic AMP more than does incubation in dibutyryl cyclic AMP. The intracellular increase of cyclic AMP is greater with Strain L than with WI-38 cells. Similarly, cell division of Strain L cells is inhibited more by cyclic AMP. The experiments do not, support the belief that dibutyryl cyclic AMP is transported better than cyclic AMP.