DNA Polymerases from RNA Tumor Viruses and Human Cells: Inhibition by Polyuridylic Acid

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Science  22 Sep 1972:
Vol. 177, Issue 4054, pp. 1111-1114
DOI: 10.1126/science.177.4054.1111


Polyuridylic acid inhibited DNA polymerases purified from three species of oncornaviruses as well as three out of seven DNA polymerases purified from cells. Viral and cellular DNA polymerases could not be distinguished by polyuridylic acid inhibition, but were easily distinguished by their template preferences in the presence of magnesium.