Axotomy Mimicked by Localized Colchicine Application

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Science  22 Sep 1972:
Vol. 177, Issue 4054, pp. 1116-1118
DOI: 10.1126/science.177.4054.1116


Comparable depression of synaptic transmission in the avian ciliary ganglion resulted from either section or localized colchicine treatment of the ciliary nerves. Both colchicine treatment and axotomny produced similar changes in RNA distribution in the cell bodies as well. Colchicine did not directly affect transmission, and action potential propagation along the ciliary nerves was normal. Interference with axoplasmic transport of material in both cases is postulated to signal the observed chromatolytic changes.