Absence of Polymerase Protein in Virions of Alpha-Type Rous Sarcoma Virus

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Science  29 Sep 1972:
Vol. 177, Issue 4055, pp. 1188-1191
DOI: 10.1126/science.177.4055.1188


Noninfectious particles of a mutant of Rous sarcoma virus failed to exhibit DNA polymerase activity even with the use of the most sensitive synthetic template-primer complexes. A neutralization blocking test against antibody to DNA polymerase revealed that these mutants did not contain protein immunologically related to the DNA polymerase.