Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats

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Science  29 Sep 1972:
Vol. 177, Issue 4055, pp. 1211-1214
DOI: 10.1126/science.177.4055.1211


Intraventricular injections of 6-hydroxydopamine produced 95 percent depletion of telencephalic norepinephrine and 62 percent depletion of striatal dopamine in rats. Treated rats maintained body weight at subnormal levels and failed to increase food intake in response to a short-term decrease in glucose utilization. After treatment with the monoamine oxidase inhibitor pargyline, 6-hydroxydopamine produced no further norepinephrine depletion but increased the dopamnine depletion to 95 percent and produced complete aphagia. These effects are comparable to events that follow bilateral electrolytic lesions of the lateral hypothalanmus.