Evidence for the Neutral Hypothesis of Protein Polymorphism

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Science  06 Oct 1972:
Vol. 178, Issue 4056, pp. 56-58
DOI: 10.1126/science.178.4056.56


Data for some 400 polymorphic proteins were examined with special reference to molecular evolution, by using a statistic that depends on neither mutation rate, population structure, nor other ecological factors. The result indicates that most of these polymorphisms are maintained in a population by mutation and random genetic drift.