Human-Mouse Cell Hybrids: A Suggestion of Structural Mutation for Dipeptidase-2 Deficiency in Mouse Cells

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Science  06 Oct 1972:
Vol. 178, Issue 4056, pp. 58-60
DOI: 10.1126/science.178.4056.58


The dipeptidase-2 enzyme is inactive in certain cultured cell lines from the mouse. In somatic cell hybrids between such deficient cells and diploid human fibroblasts, the mouse deficiency was complemented when the homologous human peptidase-A was retained. The results suggested that the murine peptidase deficiency was the result of a structural mutation, rather than a regulatory one.