Expression of Lactate and Malate Dehydrogenases in Tumors Induced by SV40 and 7,12-Dimethylbenz(a)anthracene

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Science  06 Oct 1972:
Vol. 178, Issue 4056, pp. 70-71
DOI: 10.1126/science.178.4056.70


Isozyme patterns of lactate and malate dehydrogenases were studied in tumors induced by SV40 and 7,12-dimethylbenz(a)anthracene and in established cultures of cells from these tumors. The expression of B polypeptide subunits of lactate dehydrogenase is suppressed similarly by both agents. This may be due to inactivation of the gene at the locus determining the B polypeptide subunit. Malate dehydrogenase isozyme patterns are not changed significantly by the virus or the carcinogen.