6-Hydroxydopa Depletion of Brain Norepinephrine and the Facilitation of Aggressive Behavior

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Science  06 Oct 1972:
Vol. 178, Issue 4056, pp. 75-77
DOI: 10.1126/science.178.4056.75


A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system.