Human Blood Monocytes: Stimulators of Granulocyte and Mononuclear Colony Formation in vitro

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Science  13 Oct 1972:
Vol. 178, Issue 4057, pp. 164-166
DOI: 10.1126/science.178.4057.164


Human blood monocytes in a feeder layer or by use for conditioning medium produced a colony-stimulating factor capable of stimulating the in vitro growth of colonies of granulocytes and mononuclear cells from human and murine marrow. Lymphocytes and neutrophils did not stimulate colony formation, and medium conditioned by neutrophils was inhibitory. This suggests that the monocyte may control granulocyte proliferation and maturation.