Detergent Effects on a Reverse Transcriptase Activity and on Inhibition by Rifamycin Derivatives

Science  03 Nov 1972:
Vol. 178, Issue 4060, pp. 505-507
DOI: 10.1126/science.178.4060.505


A reverse transcriptase activity, extracted from virus-transformed cells, is activated by very low concentrations of nonionic detergents. These same detergents also significantly reduce the effectiveness of certain rifamycin derivatives as inhibitors of the polymerase activity when the detergents are present at micelle-forming concentrations.